Scott Hanselman just created a really nice blog post about using different layouts and colors for VS.
I really like the fact that you can fully customise the look of visual studio, this is especially easy if you download a pre-defined package of settings. Then use the "Tools>>Import Export Settings..." menu to import downloaded settings.
Take a look at Scotts blog where there are a number of different styles, I especially like Oren Ellenbogen's Dark Scheme. Which I have downloaded and am now using (how cool am I).